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Keep track of Closely (one)pentobarbital will reduce the level or impact of fentanyl intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some decrease in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, developm

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